Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds

Shinji Ohta; Manami Takeda; Emi Ohta; Tatsuo Nehira; Hisashi Ômura; Mylene M Uy; Yasuhiro Ishihara

doi:10.1016/j.phytochem.2021.112904

Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds

Phytochemistry. 2021 Nov:191:112904. doi: 10.1016/j.phytochem.2021.112904. Epub 2021 Aug 10.

Authors

Shinji Ohta¹, Manami Takeda², Emi Ohta³, Tatsuo Nehira³, Hisashi Ômura³, Mylene M Uy⁴, Yasuhiro Ishihara⁵

Affiliations

¹ Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan. Electronic address: ohta@hiroshima-u.ac.jp.
² Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
³ Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
⁴ Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, 9200, Philippines.
⁵ Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan. Electronic address: ishiyasu@hiroshima-u.ac.jp.

PMID: 34388665
DOI: 10.1016/j.phytochem.2021.112904

Abstract

Eight hitherto undescribed long-chain anacardic acid derivatives, janohigenins, were isolated from the endosperm of Ophiopogon japonicus seed, and their structures were elucidated employing spectroscopic and chemical methods. The neuroprotective activity of the isolated compounds was evaluated against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells. Janohigenins exhibited noticeable neuroprotection at 1 μM.

Keywords: Anacardic acid derivatives; Asparagaceae; Neuroprotective activity; Ophiopogon japonicus; Seed.

MeSH terms

Anacardic Acids / pharmacology
Neuroprotection
Neuroprotective Agents* / pharmacology
Ophiopogon*
Seeds

Substances

Anacardic Acids
Neuroprotective Agents
anacardic acid