Antibiotic residues may be very harmful in aquatic environments, because of limited treatment efficiency of traditional treatment methods. An electrochemical system with a Ti-based SnO2-Sb-Ni anode was developed to degrade a typical antibiotic chloramphenicol (CAP) in water. The electrode was prepared using a sol-gel method. The performance of electrode materials, impact factors and dynamic characteristics were evaluated. The Ti-based SnO2-Sb-Ni electrode was compact and uniform as shown by characterization using SEM and XRD. The electrocatalytic oxidation of CAP was carried out in a single-chamber reactor by using a Ti-based SnO2-Sb-Ni electrode. For 100 mg L-1 CAP, the CAP removal ratio of 100% and the TOC removal ratio of 60% were obtained at the current density of 20 mA cm-2 and in a neutral electrolyte at 300 min. Kinetic investigation has shown that the electro-oxidation of CAP on a Ti-based SnO2-Sb-Ni electrode displayed a pseudo-first-order kinetic model. Free radical quenching experiments presented that the oxidation of CAP on Ti-based SnO2-Sb-Ni electrode resulted from the synergistic effect of direct oxidation and indirect oxidation (·OH and ·SO4-). Doping Ni on the Ti/SnO2-Sb electrode for CAP degradation was presented in this paper, showing its great application potential in the area of antibiotic and halogenated organic pollutant degradation.