Predictive Value of Preoperative Controlling Nutritional Status Score Combined with Fibrinogen-Albumin Ratio in Postoperative Local Recurrence-Free Survival of Patients with Retroperitoneal Liposarcoma

Guo-Qiang Xue; Cheng-Peng Li; Ang Lv; Xiu-Yun Tian; Jian-Hui Wu; Hui Qiu; Chun-Yi Hao

doi:10.2147/CMAR.S307920

Predictive Value of Preoperative Controlling Nutritional Status Score Combined with Fibrinogen-Albumin Ratio in Postoperative Local Recurrence-Free Survival of Patients with Retroperitoneal Liposarcoma

Cancer Manag Res. 2021 Aug 6:13:6157-6167. doi: 10.2147/CMAR.S307920. eCollection 2021.

Authors

Guo-Qiang Xue¹, Cheng-Peng Li¹, Ang Lv¹, Xiu-Yun Tian¹, Jian-Hui Wu¹, Hui Qiu¹, Chun-Yi Hao¹

Affiliation

¹ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China.

Abstract

Background: Previous studies have shown that nutrition and systemic inflammation plays an essential role in the development of soft tissue sarcoma. However, few studies have explored the association of clinicopathologic features and local recurrence with nutritional and inflammatory markers in retroperitoneal liposarcoma (RPLS). This study sought to evaluate the prognostic value of the preoperative nutritional and inflammatory markers for local recurrence-free survival (LRFS) among surgical RPLS patients.

Methods: The study included 111 RPLS patients who underwent surgery between May 2010 and June 2019 at the Peking University Cancer Hospital Sarcoma Center. Time-dependent receiver operating characteristic (time-ROC) curve analysis was conducted to evaluate the ability of markers to predict LRFS. The associations of the CONUT-FAR score with clinicopathological variables and LRFS were evaluated.

Results: In the time-ROC curve analysis, the CONUT-FAR score was superior to other nutritional and inflammatory markers in predicting LRFS. The CONUT-FAR score was the only nutritional and inflammatory marker that independently predicted LRFS in the multivariate analysis, and patients with a high CONUT-FAR score (> 11) showed significantly decreased LRFS. Although the CONUT-FAR score failed to discriminate patients with low grade (G1) (p = 0.327) or undergoing incomplete (R2) resection (p = 0.072), it stratified patients with high grade (G2 and G3) or undergoing complete resection (R0/R1) into subgroups with significantly distinct LRFS (p < 0.001). The CONUT-FAR score also showed good clinical utility among patients with different clinical characteristics.

Conclusion: The preoperative CONUT-FAR score reflects both nutritional and inflammatory factors and is an effective predictor of LRFS for surgical RPLS patients.

Keywords: fibrinogen–albumin ratio; nutritional status; prognostic factor; retroperitoneal liposarcoma; time-dependent ROC.

Grants and funding

This work was supported by the Capital Health Research and Development of Special Funds (approval No.: 2020-1-1021), Beijing Municipal Administration of Hospital’s Ascent Plan (approval No.: DFL20181104), and Beijing Municipal Administration of Hospitals’ Youth Programme (approval No. QML20181104), interdisciplinary medicine Seed Fund of Peking University and the Fundamental Research Funds for the Central Universities [approval No.: BMU2020MX015], Science Foundation of Peking University Cancer Hospital 2020-13 and 2020-14.