The tetraspan MS4A family in homeostasis, immunity, and disease

Irene Mattiola; Alberto Mantovani; Massimo Locati

doi:10.1016/j.it.2021.07.002

The tetraspan MS4A family in homeostasis, immunity, and disease

Trends Immunol. 2021 Sep;42(9):764-781. doi: 10.1016/j.it.2021.07.002. Epub 2021 Aug 9.

Authors

Irene Mattiola¹, Alberto Mantovani², Massimo Locati³

Affiliations

¹ Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charitè - Universitätsmedizin Berlin, Germany; Berlin Institute of Health, Berlin, Germany; Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany. Electronic address: irene.mattiola@charite.de.
² Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy; The William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address: alberto.mantovani@humanitasresearch.it.
³ Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Department of Medical Biotechnologies and Translation Medicine, University of Milan, Italy. Electronic address: massimo.locati@unimi.it.

PMID: 34384709
DOI: 10.1016/j.it.2021.07.002

Abstract

The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.

Trial registration: ClinicalTrials.gov NCT00004179.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antigens, CD20
B-Lymphocytes
Disease*
Homeostasis*
Humans
Immunity*
Macrophages
Membrane Proteins
Tetraspanins / physiology*

Substances

Antigens, CD20
MS4A4A protein, human
Membrane Proteins
Tetraspanins

Associated data

ClinicalTrials.gov/NCT00004179