atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity

Yong Wang; Xiaoguang Lu; Xiaoping Wang; Qi Qiu; Ping Zhu; Lin Ma; Xiao Ma; Joerg Herrmann; Xueying Lin; Wei Wang; Xiaolei Xu

doi:10.1161/CIRCRESAHA.121.319104

atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity

Circ Res. 2021 Oct;129(8):e166-e182. doi: 10.1161/CIRCRESAHA.121.319104. Epub 2021 Aug 13.

Authors

Yong Wang^#^{1

2

3}, Xiaoguang Lu^#^{1

2

4}, Xiaoping Wang^#³, Qi Qiu^{1

2

5}, Ping Zhu^{1

2}, Lin Ma³, Xiao Ma^{1

2}, Joerg Herrmann², Xueying Lin^{1

2}, Wei Wang³, Xiaolei Xu^{1

2}

Affiliations

¹ Biochemistry and Molecular Biology (Y.W., X. Lu, Q.Q., P.Z., X.M., X. Lin, X.X.), Mayo Clinic, Rochester, MN.
² Cardiovascular Medicine (Y.W., X. Lu, Q.Q., P.Z., X.M., J.H., X. Lin, X.X.), Mayo Clinic, Rochester, MN.
³ School of Traditional Chinese Medicine (Y.W., X.W., L.M., W.W.), Beijing University of Chinese Medicine, China.
⁴ Dongzhimen Hospital (X. Lu), Beijing University of Chinese Medicine, China.
⁵ Institute of Clinical Pharmacology, Beijing Anzhen Hospital, Capital Medical University, China (Q.Q.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: anthracycline; autophagy; cardiotoxicity; doxorubicin; zebrafish.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / toxicity*
Autophagy / drug effects*
Autophagy-Related Protein 7 / genetics
Autophagy-Related Protein 7 / metabolism
Cardiotoxicity
Doxorubicin / toxicity*
Myocarditis / drug therapy*
Myocarditis / etiology
Myocarditis / metabolism
Pravastatin / pharmacology
Pravastatin / therapeutic use*
Spironolactone / pharmacology
Spironolactone / therapeutic use*
Zebrafish
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism

Substances

Antineoplastic Agents
Zebrafish Proteins
Spironolactone
Doxorubicin
Autophagy-Related Protein 7
Pravastatin

Abstract

Publication types

MeSH terms

Substances

Grants and funding