Microneedle-Mediated Vaccination: Innovation and Translation

Tao Sheng; Bowen Luo; Wentao Zhang; Xinyang Ge; Jicheng Yu; Yuqi Zhang; Zhen Gu

doi:10.1016/j.addr.2021.113919

Microneedle-Mediated Vaccination: Innovation and Translation

Adv Drug Deliv Rev. 2021 Dec:179:113919. doi: 10.1016/j.addr.2021.113919. Epub 2021 Aug 8.

Authors

Tao Sheng¹, Bowen Luo¹, Wentao Zhang¹, Xinyang Ge², Jicheng Yu³, Yuqi Zhang⁴, Zhen Gu⁵

Affiliations

¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
² College of Letter and Science, University of California, Los Angeles, CA 90095, USA.
³ Zenomics Inc., Los Angeles, CA 90095, USA.
⁴ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of Burns and Wound Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China. Electronic address: yqzhang21@zju.edu.cn.
⁵ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: guzhen@zju.edu.cn.

PMID: 34375682
DOI: 10.1016/j.addr.2021.113919

Abstract

Vaccine administration by subcutaneous or intramuscular injection is the most commonly prescribed route for inoculation, however, it is often associated with some deficiencies such as low compliance, high professionalism, and risk of infection. Therefore, the application of microneedles for vaccine delivery has gained widespread interests in the past few years due to its high compliance, minimal invasiveness, and convenience. This review focuses on recent advances in the development and application of microneedles for vaccination based on different delivery strategies, and introduces the current status of microneedle-mediated vaccination in clinical translation. The prospects for its application including opportunities and challenges are further discussed.

Keywords: Drug delivery; Immunology; Microneedle; Transdermal delivery; Vaccination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Nanoparticles
Needles*
Skin / metabolism
Vaccines / administration & dosage*
Vaccines / immunology*

Substances

Vaccines