Tannic acid is a gastroprotective that regulates inflammation and oxidative stress

Bruno Oliveira de Veras; Márcia Vanusa da Silva; Penha Patricia Cabral Ribeiro

doi:10.1016/j.fct.2021.112482

Tannic acid is a gastroprotective that regulates inflammation and oxidative stress

Food Chem Toxicol. 2021 Oct:156:112482. doi: 10.1016/j.fct.2021.112482. Epub 2021 Aug 7.

Authors

Bruno Oliveira de Veras¹, Márcia Vanusa da Silva², Penha Patricia Cabral Ribeiro³

Affiliations

¹ Post-graduation in Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, 50670-420, Recife, Pernambuco, Brazil; Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, 50670-420, Recife, Pernambuco, Brazil. Electronic address: bruno.overas@ufpe.br.
² Department of Biochemistry, Biosciences Center, Federal University of Pernambuco, 50670-420, Recife, Pernambuco, Brazil.
³ Department of Nutrition, Health Sciences Center, Federal University of Pernambuco, 50670-420, Recife, Pernambuco, Brazil.

PMID: 34371106
DOI: 10.1016/j.fct.2021.112482

Abstract

This study investigated the gastroprotective effect of TA against gastric ulcer in mice, and its possible mechanisms of action. The effects were investigated in a model of ethanol and ethanol/HCl induced ulcers, and physical barrier test. Quantification of oxidative stress mediators and inflammatory cytokines in gastric tissue was performed. The involvement of sulfhydryl compounds (-SH), nitric oxide (NO), prostaglandin E₂ (PGE₂), potassium channels (K ⁺_ATP) and opioid receptors in gastroprotection were investigated. Oral treatment with TA at a dose of 50 mg/kg resulted in 97.96% and 94.20% (reduction in gastric injury) of gastroprotection, against injuries caused by ethanol and ethanol/HCL, respectively, in addition to having a systematic effect. TA promotes increased levels of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), as well as reduced levels of malondialdehyde (MDA) reaction to thiobarbituric acid and myeloperoxidase (MPO). In addition, there was reduction in levels of tumor necrosis factor alpha (TNF-α) and interleukins (IL) IL-1β and IL-6 and increased IL-10. The gastroprotective activity of TA involved K ⁺_ATP channels and the production of -SH, NO and PGE_2, demonstrating multiple mechanisms of action. The results of the present study suggest that TA may be a gastroprotective agent counteracting oxidative and inflammatory stress.

Keywords: Gastroprotection; Inflammation; Mechanisms; Oxidative stress; Systemic effect; Tannins.

MeSH terms

Animals
Female
Inflammation / prevention & control*
Male
Mice
Oxidative Stress / drug effects*
Stomach Ulcer / prevention & control*
Tannins / pharmacology*

Substances

Tannins