Targeting ITK signaling for T cell-mediated diseases

Samuel Weeks; Rebecca Harris; Mobin Karimi

doi:10.1016/j.isci.2021.102842

Targeting ITK signaling for T cell-mediated diseases

iScience. 2021 Jul 14;24(8):102842. doi: 10.1016/j.isci.2021.102842. eCollection 2021 Aug 20.

Authors

Samuel Weeks¹, Rebecca Harris¹, Mobin Karimi¹

Affiliation

¹ Department of Microbiology and Immunology, SUNY Upstate Medical University, 766 Irving Avenue Weiskotten Hall Suite 2281, Syracuse, NY 13210, USA.

Abstract

The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.

Keywords: Biochemistry; Biological sciences; Cell biology; Immunology; Molecular biology.

Publication types

Review

Abstract

Publication types

Grants and funding