Induction Strategy for Locally Advanced Thymoma

Yang Zhang; Zongjuan Li; Yixing Chen; Lijie Tan; Zhaochong Zeng; Jianyong Ding; Shisuo Du

doi:10.3389/fonc.2021.704220

Induction Strategy for Locally Advanced Thymoma

Front Oncol. 2021 Jul 22:11:704220. doi: 10.3389/fonc.2021.704220. eCollection 2021.

Authors

Yang Zhang¹, Zongjuan Li¹, Yixing Chen¹, Lijie Tan², Zhaochong Zeng¹, Jianyong Ding², Shisuo Du¹

Affiliations

¹ Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract

Surgery remains cornerstone for the management of thymoma. Complete surgical resection (R0), is recognized as the constant and significant factor for prognosis. However, in locally advanced (Masaoka-Koga stages III-IVa) thymomas, achieving R0 resection remains challenging due to local-regional invasion of the disease. Induction treatment, with the aim of reducing bulky tumor mass, offers new strategy to facilitate totally surgical resection. Herein, we reviewed recent progress and provided a comprehensive overview of induction strategy in locally advance thymoma.

Keywords: R0 resection; induction therapy; locally advanced; neoadjuvant; thymoma.

Publication types

Review