SYTL3- SLC22A3 Single-Nucleotide Polymorphisms and Gene-Gene/Environment Interactions on the Risk of Hyperlipidemia

Peng-Fei Zheng; Rui-Xing Yin; Xiao-Li Cao; Yao-Zong Guan; Guo-Xiong Deng; Bi-Liu Wei; Chun-Xiao Liu

doi:10.3389/fgene.2021.679027

SYTL3- SLC22A3 Single-Nucleotide Polymorphisms and Gene-Gene/Environment Interactions on the Risk of Hyperlipidemia

Front Genet. 2021 Jul 21:12:679027. doi: 10.3389/fgene.2021.679027. eCollection 2021.

Authors

Peng-Fei Zheng¹, Rui-Xing Yin^{1

2

3}, Xiao-Li Cao⁴, Yao-Zong Guan¹, Guo-Xiong Deng¹, Bi-Liu Wei¹, Chun-Xiao Liu¹

Affiliations

¹ Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
² Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular Disease Control and Prevention, Nanning, China.
³ Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, Nanning, China.
⁴ Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Abstract

The current study aims to further delineate the associations between the synaptotagmin-like 3 (SYTL3) and solute carrier family 22 member 3 (SLC22A3) single-nucleotide polymorphisms (SNPs) and their haplotypes and gene-gene (G × G)/environment (G × E) interactions on the risk of hyperlipidemia (HLP) in the Maonan and Han ethnic groups. Genotype distribution among the SYTL3-SLC22A3 SNPs in 2,829 individual patients bearing no relationship to each other (Han, 1,436; Maonan, 1,393) was analyzed utilizing next-generation sequencing techniques. The genotype frequencies of the rs6455600, rs2129209, and rs446809 SNPs were varied between the two ethnic groups (P < 0.05-0.001). Various SNPs were correlated with serum levels of triglyceride (TG; rs446809), total cholesterol (TC; rs6455600, rs2129209, and rs539298), and low-density lipoprotein cholesterol (LDL-C; rs446809) among the Han population, whereas various SNPs were also correlated with TC (rs6455600 and rs539298), TG (rs446809), and LDL-C (rs446809) levels in the Maonan ethnic group (P < 0.008-0.001). One part of haplotypes resulted in worsened HLP-related morbidity in the Han (SYTL3 A-C-A-A; SLC22A3 A-A and A-G; and SYTL3-SLC22A3 A-C-A-A-A-A and A-C-A-A-A-G) and Maonan (SYTL3 A-C-A-A; SLC22A3 A-A and A-G; and SYTL3-SLC22A3 A-C-A-A-A-A, G-T-C-A-A-A, and G-T-C-A-C-A) ethnic groups, whereas another part of haplotypes lowered HLP-related health risks in the Han (SLC22A3 C-A and C-G and SYTL3-SLC22A3 A-C-A-A-C-A, A-C-A-A-C-G, and G-T-C-A-C-A) and Maonan (SLC22A3 C-G and SYTL3-SLC22A3 A-C-A-A-C-G) ethnic groups. We discovered that the SYTL3-SLC22A3 SNPs and their haplotypes were associated with serum lipid levels and the risk of HLP in our studied populations.

Keywords: environmental factor; haplotype; hyperlipidaemia; interaction; single nucleotide polymorphism; solute carrier family 22 member 3; synaptotagmin like 3.