Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

Melitini Koutsoviti; Angeliki Siamidi; Panagoula Pavlou; Marilena Vlachou

doi:10.3390/ma14154290

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

Materials (Basel). 2021 Jul 31;14(15):4290. doi: 10.3390/ma14154290.

Authors

Melitini Koutsoviti¹, Angeliki Siamidi¹, Panagoula Pavlou², Marilena Vlachou¹

Affiliations

¹ Department of Pharmacy, Division of Pharmaceutical Technology, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece.
² Department of Biomedical Sciences, Division of Aesthetics and Cosmetic Science, University of West Attica, 28 Ag. Spyridonos Str., 12243 Egaleo, Greece.

Abstract

In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

Keywords: PLGA; PVCL-PVA-PEG; cetalkonium chloride; chitosan; excipients; eye; gelatin; hyaluronic acid; ocular drug delivery; poloxamer.

Publication types

Review