MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease

Vanessa Desantis; Antonio Giovanni Solimando; Ilaria Saltarella; Antonio Sacco; Viviana Giustini; Marta Bento; Aurelia Lamanuzzi; Assunta Melaccio; Maria Antonia Frassanito; Angelo Paradiso; Monica Montagnani; Angelo Vacca; Aldo M Roccaro

doi:10.3390/cancers13153650

MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease

Cancers (Basel). 2021 Jul 21;13(15):3650. doi: 10.3390/cancers13153650.

Authors

Affiliations

¹ Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.
² Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
³ IRCCS Istituto Tumori "Giovanni Paolo II" of Bari, 70124 Bari, Italy.
⁴ Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
⁵ Centro Hospitalar Lisboa Norte, Department of Hematology and Transplantation, Institute of Molecular Medicine, University of Lisbon, 1649-035 Lisbon, Portugal.
⁶ Unit of General Pathology, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Abstract

Multiple myeloma (MM) is a hematological malignancy characterised by proliferation of clonal plasma cells (PCs) within the bone marrow (BM). Myelomagenesis is a multi-step process which goes from an asymptomatic phase, defined as monoclonal gammopathy of undetermined significance (MGUS), to a smouldering myeloma (SMM) stage, to a final active MM disease, characterised by hypercalcemia, renal failure, bone lesions anemia, and higher risk of infections. Overall, microRNAs (miRNAs) have shown to significantly impact on MM tumorigenesis, as a result of miRNA-dependent modulation of genes involved in pathways known to be crucial for MM pathogenesis and disease progression. We aim to revise the literature related to the role of miRNAs as potential diagnostic and prognostic biomarkers, thus highlighting their key role as novel players within the field of MM and related premalignant conditions.

Keywords: miRNA-based therapy; microRNAs; monoclonal gammopathy of undetermined significance; multiple myeloma; myelomagenesis.

Publication types

Review

Abstract

Publication types

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