Infection makes micro-CHIPs into macro-CHIPs

Jayakrishnan Gopakumar; Siddhartha Jaiswal

doi:10.1016/j.stem.2021.07.006

Infection makes micro-CHIPs into macro-CHIPs

Cell Stem Cell. 2021 Aug 5;28(8):1335-1336. doi: 10.1016/j.stem.2021.07.006.

Authors

Jayakrishnan Gopakumar¹, Siddhartha Jaiswal²

Affiliations

¹ Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA.
² Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: sjaiswal@stanford.edu.

PMID: 34358435
DOI: 10.1016/j.stem.2021.07.006

Abstract

In this issue of Cell Stem Cell, Hormaechea-Agulla et al. (2021) demonstrate that IFNγ signaling following an infection in mice provides a selective pressure that drives growth of Dnmt3a^-/- hematopoietic stem cells. This clonal expansion is mediated by global methylation changes that lead to an increased self-renewing capacity.

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MeSH terms

Animals
DNA (Cytosine-5-)-Methyltransferases*
Hematopoietic Stem Cells*
Mice

Substances

DNA (Cytosine-5-)-Methyltransferases