Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents

Abstract

Thiazolidinedione, an important heterocyclic ring system, is a pharmacophore and a privileged scaffold in medicinal chemistry. Researchers have shown its potential application as a backbone for inhibitors, as it is involved in anticancer development strategies, cancer progression and metastasis. In this paper, the anticancer activities of thiazolidinedione derivatives were reviewed for the first time with respect to different substituents and their positions. This work may imitate a stirring wheel to guide further advanced development of new anticancer molecules with high efficacy.

Keywords: 3D-QSAR; Anticancer; Inhibitors; Molecular Docking.; Structure-activity relationship; Thiazolidinedione.