The Vital Roles of LINC00662 in Human Cancers

Yuting He; Yating Xu; Xiao Yu; Zongzong Sun; Wenzhi Guo

doi:10.3389/fcell.2021.711352

The Vital Roles of LINC00662 in Human Cancers

Front Cell Dev Biol. 2021 Jul 20:9:711352. doi: 10.3389/fcell.2021.711352. eCollection 2021.

Authors

Yuting He^{1

2

3

4}, Yating Xu^{1

2

3

4}, Xiao Yu^{1

2

3

4}, Zongzong Sun⁵, Wenzhi Guo^{1

2

3

4}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ, Transplantation at Henan Universities, Zhengzhou, China.
⁴ Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, China.
⁵ Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Long non-coding RNAs (lncRNAs) play crucial roles in many human diseases, particularly in tumorigenicity and progression. Although lncRNA research studies are increasing rapidly, our understanding of lncRNA mechanisms is still incomplete. The long intergenic non-protein coding RNA 662 (LINC00662) is a novel lncRNA, and accumulating evidence suggests that it is related to a variety of tumors in multiple systems, including the respiratory, reproductive, nervous, and digestive systems. LINC00662 has been shown to be upregulated in malignant tumors and has been confirmed to promote the development of malignant tumors. LINC00662 has also been reported to facilitate a variety of cellular events, such as tumor-cell proliferation, invasion, and migration, and its expression has been correlated to clinicopathological characteristics in patients with tumors. In terms of mechanisms, LINC00662 regulates gene expression by interacting with both proteins and with RNAs, so it may be a potential biomarker for cancer diagnosis, prognosis, and treatment. This article reviews the expression patterns, biological functions, and underlying molecular mechanisms of LINC00662 in tumors.

Keywords: LINC00662; competing endogenous RNA; molecular mechanism; oncogene; proliferation.

Publication types

Review