Perspective of Future SERS Clinical Application Based on Current Status of Raman Spectroscopy Clinical Trials

Xi Xi; Chongyang Liang

doi:10.3389/fchem.2021.665841

Perspective of Future SERS Clinical Application Based on Current Status of Raman Spectroscopy Clinical Trials

Front Chem. 2021 Jul 20:9:665841. doi: 10.3389/fchem.2021.665841. eCollection 2021.

Authors

Xi Xi¹, Chongyang Liang²

Affiliations

¹ Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
² School of pharmaceutical science, Institute of Frontier Medical Science, Jilin University, Changchun, China.

Abstract

Raman spectroscopy has emerged as a promising tool in biomedical analysis and clinical diagnosis. The development of surface-enhanced Raman scattering spectroscopy (SERS) improved the detection limit with ultrahigh sensitivity and simplicity. More and more Raman spectroscopy clinical trials (R-PCT) have been conducted recently. However, there is a lack of an up-to-date review summarizing the current status of Raman clinical trials performed until now. Hence, the clinical trials for Raman were retrieved from the International Clinical Trials Registration Platform. We summarized the clinical characteristics of 55 registered Raman spectroscopy clinical trials (R-RSCTs) and 44 published Raman spectroscopy clinical trials (P-RSCTs). This review could assist researchers and clinicians to understand the current status of Raman spectroscopy clinical research and perhaps could benefit the reasonable and accurate design of future SERS studies.

Keywords: clinical trial; disease; raman spectroscopy; sample selection; surface-enhanced raman spectroscopy.

Publication types

Review