Automated Diagnosis of COVID-19 Using Deep Supervised Autoencoder With Multi-View Features From CT Images

IEEE/ACM Trans Comput Biol Bioinform. 2022 Sep-Oct;19(5):2723-2736. doi: 10.1109/TCBB.2021.3102584. Epub 2022 Oct 10.

Abstract

Accurate and rapid diagnosis of coronavirus disease 2019 (COVID-19) from chest CT scans is of great importance and urgency during the worldwide outbreak. However, radiologists have to distinguish COVID-19 pneumonia from other pneumonia in a large number of CT scans, which is tedious and inefficient. Thus, it is urgently and clinically needed to develop an efficient and accurate diagnostic tool to help radiologists to fulfill the difficult task. In this study, we proposed a deep supervised autoencoder (DSAE) framework to automatically identify COVID-19 using multi-view features extracted from CT images. To fully explore features characterizing CT images from different frequency domains, DSAE was proposed to learn the latent representation by multi-task learning. The proposal was designed to both encode valuable information from different frequency features and construct a compact class structure for separability. To achieve this, we designed a multi-task loss function, which consists of a supervised loss and a reconstruction loss. Our proposed method was evaluated on a newly collected dataset of 787 subjects including COVID-19 pneumonia patients, other pneumonia patients, and normal subjects without abnormal CT findings. Extensive experimental results demonstrated that our proposed method achieved encouraging diagnostic performance and may have potential clinical application for the diagnosis of COVID-19.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19 Testing
  • COVID-19* / diagnostic imaging
  • Deep Learning*
  • Humans
  • Pneumonia*
  • SARS-CoV-2
  • Tomography, X-Ray Computed

Grants and funding

This work was supported in part by Key Emergency Project of Pneumonia Epidemic of novel coronavirus infection under Grant 2020SK3006, Emergency Project of Prevention and Control for COVID-19 of Central South University under Grant 160260005, Foundation from Changsha Scientific and Technical bureau, China under Grant kq2001001 National Natural Science Foundation of China under Grants 61802442, 61877059, Natural Science Foundation of Hunan Province under Grant 2019JJ50775, 111 Project under Grant B18059, the Hunan Provincial Science and Technology Program under Grant 2018WK4001, the Hunan Provincial Science and Technology Innovation Leading Plan under Grant 2020GK2019, the Science and Technology Innovation Program of Hunan Province under Grant 2020SK53423, and Clinical Research Center for Medical Imaging In Hunan Province under Grant 2020SK4001.