A Neonate with Acquired Factor VII Deficiency Successfully Managed with Immunomodulatory Therapy

Nof Saadi Alqarni; Ali H Algiraigri

doi:10.1016/j.ijpam.2020.12.002

A Neonate with Acquired Factor VII Deficiency Successfully Managed with Immunomodulatory Therapy

Int J Pediatr Adolesc Med. 2021 Sep;8(3):195-197. doi: 10.1016/j.ijpam.2020.12.002. Epub 2020 Dec 9.

Authors

Nof Saadi Alqarni^{1

2}, Ali H Algiraigri^{1

2}

Affiliations

¹ Hematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
² Oncology Department, King Faisal Special Hospital and Research Center, Jeddah, Saudi Arabia.

Abstract

Acquired factor VII deficiency secondary to circulating inhibitors is rare in children but is a potentially life-threatening condition. Such a disease is challenging to diagnose and often difficult to manage. Here, we report on a newborn that presented with a catastrophic intracranial hemorrhage who failed to respond to conventional supportive measures including multiple doses of fresh frozen plasma and factor VII replacement; however, he had a complete correction of prothrombin time 8 h after immunomodulatory therapies in the form of steroid and intravenous immunoglobulin. Such measures helped stabilize his bleeding and allowed urgent neurosurgical intervention.

Keywords: Children; Factor VII; Inhibitor.

Publication types

Case Reports