Hair Cell Protection from Ototoxic Drugs

Peng Wu; Xianmin Wu; Chunhong Zhang; Xiaoyun Chen; Yideng Huang; He Li

doi:10.1155/2021/4909237

Hair Cell Protection from Ototoxic Drugs

Neural Plast. 2021 Jul 11:2021:4909237. doi: 10.1155/2021/4909237. eCollection 2021.

Authors

Peng Wu¹, Xianmin Wu¹, Chunhong Zhang¹, Xiaoyun Chen¹, Yideng Huang¹, He Li¹

Affiliation

¹ Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, 325000 Zhejiang Province, China.

Abstract

Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis / drug effects*
Hair Cells, Auditory / drug effects*
Hair Cells, Auditory / metabolism
Humans
Neuroprotective Agents / therapeutic use*
Ototoxicity / metabolism
Ototoxicity / prevention & control*
Oxidative Stress / drug effects
Reactive Oxygen Species / metabolism

Substances

Neuroprotective Agents
Reactive Oxygen Species