Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Li Lei; Shuaifeng Yang; Xiaoyang Lu; Yongfa Zhang; Tao Li

doi:10.3389/fnagi.2021.698601

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Front Aging Neurosci. 2021 Jul 15:13:698601. doi: 10.3389/fnagi.2021.698601. eCollection 2021.

Authors

Li Lei¹, Shuaifeng Yang¹, Xiaoyang Lu², Yongfa Zhang¹, Tao Li¹

Affiliations

¹ Department of Neurosurgery, The First People's Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, China.
² Translational Neurosurgery and Neurobiology, University Hospital Aachen, RWTH Aachen, Aachen, Germany.

Abstract

Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.

Keywords: FUNDC1; NIX/BNIP3; PINK1/Parkin; cerebral stroke; mitochondrial autophagy.

Publication types

Review