Cell-free DNA as a diagnostic tool for human echinococcosis

Yanping Zhao; Shu Shen; Xin Jin; Wentao Wang; Junhua Li; Weijun Chen

doi:10.1016/j.pt.2021.07.006

Cell-free DNA as a diagnostic tool for human echinococcosis

Trends Parasitol. 2021 Nov;37(11):943-946. doi: 10.1016/j.pt.2021.07.006. Epub 2021 Jul 29.

Authors

Yanping Zhao¹, Shu Shen², Xin Jin³, Wentao Wang⁴, Junhua Li⁵, Weijun Chen⁶

Affiliations

¹ BGI-Shenzhen, Shenzhen 518000, China; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen 518000, China.
² Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
³ BGI-Shenzhen, Shenzhen 518000, China.
⁴ Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: wwtdoctor02@163.com.
⁵ BGI-Shenzhen, Shenzhen 518000, China; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen 518000, China. Electronic address: lijunhua@genomics.cnlijunhua@genomics.cn.
⁶ College of Life Science, University of Chinese Academy of Sciences, Shenzhen 518083, China; BGI PathoGenesis Pharmaceutical Technology, BGI-Shenzhen, Shenzhen 518000, China. Electronic address: chenwj@genomics.cnchenwj@genomics.cn.

PMID: 34334318
DOI: 10.1016/j.pt.2021.07.006

Abstract

Echinococcosis is a major public health problem and an emerging/re-emerging disease. It was proposed that Echinococcus cell-free DNA (cfDNA) could be used in diagnosing human echinococcosis, though earlier attempts failed. Here, we update the research on detecting Echinococcus cfDNA in echinococcosis patients' samples and highlight future research directions.

Keywords: Echinococcus; cell-free DNA; diagnosis; echinococcosis; humans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell-Free Nucleic Acids* / genetics
Echinococcosis* / diagnosis
Echinococcus* / genetics
Humans

Substances

Cell-Free Nucleic Acids