Unexpectedly rigid short peptide foldamers in which NH-π and CH-π interactions are preserved in solution

Luhan Zhai; Masayuki Nara; Yuko Otani; Tomohiko Ohwada

doi:10.1039/d1cc02998c

Unexpectedly rigid short peptide foldamers in which NH-π and CH-π interactions are preserved in solution

Chem Commun (Camb). 2021 Aug 28;57(67):8344-8347. doi: 10.1039/d1cc02998c. Epub 2021 Jul 30.

Authors

Luhan Zhai¹, Masayuki Nara, Yuko Otani, Tomohiko Ohwada

Affiliation

¹ Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ko, Tokyo, 113-0033, Japan. ohwada@mol.f.u-tokyo.ac.jp.

PMID: 34328149
DOI: 10.1039/d1cc02998c

Abstract

NH-π and CH-π interactions, due to their weak character, are not easily identified in solution. We report a group of isolable short peptides with stable folds, in which NH-π and CH-π main chain-side chain interactions can be detected in solution by means of NMR and ATR-IR spectroscopy.