Management of Postural Orthostatic Tachycardia Syndrome in the Absence of Randomized Controlled Trials

Asim Kichloo; Michael Aljadah; Blair Grubb; Khalil Kanjwal

doi:10.19102/icrm.2021.120705

Management of Postural Orthostatic Tachycardia Syndrome in the Absence of Randomized Controlled Trials

J Innov Card Rhythm Manag. 2021 Jul 15;12(7):4607-4612. doi: 10.19102/icrm.2021.120705. eCollection 2021 Jul.

Authors

Asim Kichloo^{1

2}, Michael Aljadah³, Blair Grubb⁴, Khalil Kanjwal⁵

Affiliations

¹ Department of Internal Medicine, Central Michigan University, Saginaw, MI, USA.
² Department of Internal Medicine, Samaritan Medical Center, Watertown, NY, USA.
³ Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
⁴ Section of Electrophysiology, The University of Toledo Medical Center, Toledo, OH, USA.
⁵ Section of Electrophysiology, Michigan State University McLaren Greater Lansing, Lansing, MI, USA.

Abstract

Postural orthostatic tachycardia syndrome (POTS) is a clinical syndrome causing patients to experience light-headedness, palpitations, tremors, and breathlessness upon assuming an upright posture. Despite the absence of available long-term, multicenter, randomized controlled trial data, this literature review aims to concisely present the nonpharmacological and pharmacological interventions that have been used in the treatment of POTS reported to date by cross-sectional studies, cohort studies, and retrospective studies. We attempt to classify treatments as first-, second-, and third-line therapies based on our own experience and available data.

Keywords: Managemen; nonpharmacological; pharmacological; postural orthostatic tachycardia syndrome.