Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Li Huang; Sen-Te Wang; Han-Pin Kuo; Christophe Delclaux; Megan E Jensen; Lisa G Wood; Dirceu Costa; Dariusz Nowakowski; Iwona Wronka; Paula D Oliveira; Yi-Chun Chen; Yang-Ching Chen; Yungling L Lee

doi:10.1111/obr.13327

Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Obes Rev. 2021 Dec;22(12):e13327. doi: 10.1111/obr.13327. Epub 2021 Jul 28.

Authors

Li Huang¹, Sen-Te Wang^{1

2}, Han-Pin Kuo³, Christophe Delclaux⁴, Megan E Jensen⁵, Lisa G Wood⁶, Dirceu Costa⁷, Dariusz Nowakowski⁸, Iwona Wronka⁹, Paula D Oliveira¹⁰, Yi-Chun Chen¹¹, Yang-Ching Chen^{1

2

12

13}, Yungling L Lee^{14

15}

Affiliations

¹ Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
² Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Pediatric Physiology and Sleep Center, AP-HP, Robert Debré Hospital, Paris, France.
⁵ Priority Research Centre Grow Up Well and School of Medicine & Public Health, University of Newcastle, Newcastle, Australia.
⁶ Priority Research Centre for Healthy Lungs, School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, Australia.
⁷ Rehabilitation Sciences Postgraduate Program, University Nove de Julho, Sao Paulo, Brazil.
⁸ Department of Anthropology, Wroclaw University of Environmental and Life Science, Wroclaw, Poland.
⁹ Laboratory of Anthropology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.
¹⁰ Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
¹¹ Department of Health Management, I-Shou University, Kaohsiung, Taiwan.
¹² School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
¹³ Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
¹⁴ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
¹⁵ College of Public Health, China Medical University, Taichung, Taiwan.

PMID: 34322972
DOI: 10.1111/obr.13327

Abstract

Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children. The main outcomes were forced expiratory volume in 1 s (FEV₁ ), forced vital capacity (FVC), and their ratio (FEV₁ /FVC). We compared individuals with overweight or with obesity with individuals with normal weight. Random-effects models were used to calculate pooled estimates. A total of 17 studies were included. Individuals with obesity had a lower FEV₁ /FVC ratio (mean difference [MD] = -3.61%; 95% confidence interval [CI] = -4.58%, -2.64%) and a higher percent-predicted FVC (MD = 3.33%; 95% CI = 0.79%, 5.88%) than those with normal weight. Obesity impaired pulmonary function in the obstructive pattern during childhood to young adulthood, and the maximum obstruction was observed at the age of 16 years in boys and 20 years in girls. The effects attenuated at approximately 30 years and then shifted to the restrictive pattern after 35 years of age in men and 40 years in women. The effects of obesity on pulmonary function change from the obstructive pattern in childhood to the restrictive pattern in adulthood.

Keywords: forced vital capacity; obesity; obstructive lung pattern; pulmonary function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Adult
Child
Female
Forced Expiratory Volume
Humans
Lung*
Male
Obesity*
Respiratory Function Tests
Vital Capacity
Young Adult