Sequential development of ANCA-associated vasculitis and anti-GBM disease: A report of two cases

Camille Le Moine; Noémie Jourde-Chiche; Delphine Kemlin; Benjamin Terrier; Frédéric Vandergheynst

doi:10.1002/ccr3.4553

Sequential development of ANCA-associated vasculitis and anti-GBM disease: A report of two cases

Clin Case Rep. 2021 Jul 23;9(7):e04553. doi: 10.1002/ccr3.4553. eCollection 2021 Jul.

Authors

Camille Le Moine¹, Noémie Jourde-Chiche^{2

3}, Delphine Kemlin⁴, Benjamin Terrier^{3

5}, Frédéric Vandergheynst^{1

3}

Affiliations

¹ Department of Internal Medicine. Hôpital Erasme Brussels Belgium.
² Department of Nephrology Hôpital de la Conception Marseille France.
³ French Vasculitis Study Group Paris France.
⁴ Department of Nephrology Hôpital Erasme Brussels Belgium.
⁵ Department of Internal Medicine National Referral Center for Rare Systemic Autoimmune Diseases. Hôpital Cochin Paris France.

Abstract

In case of AAV with kidney involvement, physicians should explore anti-GBM antibodies and be aware of the possible sequential development of AAV, especially with MPO-ANCA, and anti-GBM glomerulonephritis. This sequential disease history is associated with a poor renal outcome, highlighting the need for urgent diagnosis and management.

Keywords: ANCA‐associated vasculitis; anti‐GBM disease; glomerulonephritis; myeloperoxidase.

Publication types

Case Reports