Genome wide analysis implicates upregulation of proteasome pathway in major depressive disorder

Shaked Belaish; Ifat Israel-Elgali; Guy Shapira; Israel Krieger; Aviv Segev; Uri Nitzan; Michael Majer; Yuval Bloch; Abraham Weizman; David Gurwitz; Noam Shomron; Libi Hertzberg

doi:10.1038/s41398-021-01529-x

Genome wide analysis implicates upregulation of proteasome pathway in major depressive disorder

Transl Psychiatry. 2021 Jul 28;11(1):409. doi: 10.1038/s41398-021-01529-x.

Authors

Shaked Belaish¹, Ifat Israel-Elgali^{1

2}, Guy Shapira^{1

3}, Israel Krieger^{1

4}, Aviv Segev^{1

4}, Uri Nitzan^{1

4}, Michael Majer⁵, Yuval Bloch^{1

4}, Abraham Weizman^{1

2

6}, David Gurwitz^{1

2}, Noam Shomron^{7

8

9}, Libi Hertzberg^{10

11

12}

Affiliations

¹ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
² Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel.
³ Edmond J. Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv, Israel.
⁴ Shalvata Mental Health Center, Hod Hasharon, Israel.
⁵ Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
⁶ Geha Mental Health Center and Felsenstein Medical Research Cener, Petah Tikva, Israel.
⁷ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. nshomron@post.tau.ac.il.
⁸ Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel. nshomron@post.tau.ac.il.
⁹ Edmond J. Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv, Israel. nshomron@post.tau.ac.il.
¹⁰ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. libi.hertzberg@gmail.com.
¹¹ Shalvata Mental Health Center, Hod Hasharon, Israel. libi.hertzberg@gmail.com.
¹² Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel. libi.hertzberg@gmail.com.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Depressive Disorder, Major* / genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Proteasome Endopeptidase Complex / genetics
Up-Regulation

Substances

Proteasome Endopeptidase Complex