West Syndrome in Children With Congenital Zika Virus Infection

Pediatr Infect Dis J. 2021 Dec 1;40(12):1108-1110. doi: 10.1097/INF.0000000000003230.

Abstract

Congenital Zika infection has been linked with a characteristic phenotype including neurologic sequelae. However, West syndrome has not been previously well described as a consequence. We aim to show this association through a retrospective descriptive study performed in Ecuador. Among 147 infants with congenital Zika infection, 7.5% suffered from West syndrome. Vigabatrin seems to be effective to control the spasms.

MeSH terms

  • Anticonvulsants / therapeutic use
  • Ecuador / epidemiology
  • Female
  • Humans
  • Infant
  • Male
  • Microcephaly / virology
  • Phenotype
  • Pregnancy
  • Pregnancy Complications, Infectious / virology
  • Retrospective Studies
  • Spasms, Infantile / drug therapy
  • Spasms, Infantile / epidemiology
  • Spasms, Infantile / virology*
  • Vigabatrin / therapeutic use
  • Zika Virus / pathogenicity*
  • Zika Virus Infection / complications*
  • Zika Virus Infection / congenital*

Substances

  • Anticonvulsants
  • Vigabatrin