Abstract
Porphyrin-incorporating covalent organic frameworks were synthesized at room temperature. The resulting products with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated the significant antitumor efficiency via sonodynamic therapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Metal-Organic Frameworks / chemical synthesis
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Mice
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Molecular Structure
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplasms / therapy*
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Optical Imaging
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Particle Size
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Porphyrins / chemistry
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Porphyrins / pharmacology*
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Singlet Oxygen / chemistry
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Singlet Oxygen / metabolism
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Temperature
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Ultrasonic Therapy*
Substances
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Antineoplastic Agents
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Metal-Organic Frameworks
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Porphyrins
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Singlet Oxygen