Siblings With Familial Dwarfism Presenting With Acute Myocardial Infarction at Adolescence

Hyun Chung; Soo Yeon Kim; Jeehoon Kang; Ji Hoon Phi; Woong-Han Kim; Sei Won Yang; Hye Won Kwon; Sang Yoon Lee; Gi Beom Kim; Eun Jung Bae; Mi Kyoung Song; Jong-Hee Chae

doi:10.1016/j.jaccas.2021.03.015

Siblings With Familial Dwarfism Presenting With Acute Myocardial Infarction at Adolescence

JACC Case Rep. 2021 May 19;3(5):795-800. doi: 10.1016/j.jaccas.2021.03.015. eCollection 2021 May.

Authors

Hyun Chung¹, Soo Yeon Kim^{2

3}, Jeehoon Kang⁴, Ji Hoon Phi⁵, Woong-Han Kim⁶, Sei Won Yang¹, Hye Won Kwon¹, Sang Yoon Lee¹, Gi Beom Kim¹, Eun Jung Bae¹, Mi Kyoung Song¹, Jong-Hee Chae^{2

3}

Affiliations

¹ Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
² Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea.
⁴ Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea.
⁵ Division of Pediatric Neurosurgery, Department of Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea.
⁶ Department of Thoracic and Cardiovascular Surgery, Seoul National University Children's Hospital, Seoul, Republic of Korea.

Abstract

We encountered siblings with familial Majewski osteodysplastic primordial dwarfism type II (MOPD II) with acute myocardial infarction in adolescence and in their early 20s. We successfully performed percutaneous and surgical coronary interventions. From these cases, we were able to better understand coronary artery disease of MOPD II and provide better management. (Level of Difficulty: Intermediate.).

Keywords: AMI, acute myocardial infarction; CABG, coronary artery bypass grafting; CAD, coronary artery disease; CAG, coronary angiography; ECG, electrocardiogram; HOMA-IR, homeostatic model assessment for insulin resistance; LAD, left anterior descending artery; LCX, left circumflex artery; MOPD II, Majewski osteodysplastic primordial dwarfism type II; PCNT, pericentrin gene; coronary artery disease; insulin resistance; pediatric; primordial dwarfism.

Publication types

Case Reports