A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury. A kidney biopsy was performed and suggested acute tubular injury. The serum creatinine returned to baseline after discontinuation of alirocumab. (Level of Difficulty: Intermediate.).
Keywords: AKI, acute kidney injury; ASCVD, atherosclerotic cardiovascular disease; CAD, coronary artery disease; CKD, chronic kidney disease; IFTA, interstitial fibrosis and atrophy; LDL-C, low-density lipoprotein-cholesterol; PCSK9-I, proprotein convertase subtilisin/kexin type 9 inhibitor; SCr, serum creatinine; cardiovascular disease; hypercholesterolemia; secondary prevention.