The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment

Hanyu Zhang; Min Yang; Xu Wu; Qianxiu Li; Xin Li; Yueshui Zhao; Fukuan Du; Yu Chen; Zhigui Wu; Zhangang Xiao; Jing Shen; Qinglian Wen; Wei Hu; Chi Hin Cho; Meijuan Chen; Yejiang Zhou; Mingxing Li

doi:10.1016/j.phrs.2021.105785

The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment

Pharmacol Res. 2021 Sep:171:105785. doi: 10.1016/j.phrs.2021.105785. Epub 2021 Jul 24.

Authors

Hanyu Zhang¹, Min Yang², Xu Wu², Qianxiu Li², Xin Li³, Yueshui Zhao², Fukuan Du², Yu Chen², Zhigui Wu⁴, Zhangang Xiao², Jing Shen², Qinglian Wen⁵, Wei Hu⁶, Chi Hin Cho⁷, Meijuan Chen⁸, Yejiang Zhou⁹, Mingxing Li¹⁰

Affiliations

¹ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; Nanchong Key Laboratory of Individualized Drug Therapy, Department of Pharmacy, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong 637000, Sichuan, China.
² Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
³ Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
⁴ Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
⁵ Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, Sichuan, China.
⁶ Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, Guangzhou, China.
⁷ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
⁸ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address: chenmeijuan1969@sina.com.
⁹ Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address: zyj7525@163.com.
¹⁰ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China. Electronic address: starlee@swmu.edu.cn.

PMID: 34311072
DOI: 10.1016/j.phrs.2021.105785

Abstract

Gastric cancer (GC) development is a complex process displaying polytropic cell and molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME, including fibroblasts, endothelial cells, mesenchymal stem cells, and various immune cells, support tumor growth, metastasis, and recurrence, functioning as the soil for gastric tumorigenesis. Importantly, exosomes secreted by either stromal cells or tumor cells during tumor-stroma crosstalk perform as crucial transporter of agents including RNAs and proteins for cell-cell communication in GC pathogenesis. Therefore, given the distinct roles of exosomes secreted by various cell types in GC TME, increasing evidence has indicated that exosomes present as new biomarkers for GC diagnosis and prognosis and shed light on novel approaches for GC treatment.

Keywords: Biomarker; Exosome; Gastric cancer; Tumor microenvironment; Tumor-stroma crosstalk.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Exosomes*
Humans
Stomach Neoplasms*
Stromal Cells*
Tumor Microenvironment*