Compliance with NPIs and possible deleterious effects on mitigation of an epidemic outbreak

Infect Dis Model. 2021:6:859-874. doi: 10.1016/j.idm.2021.06.001. Epub 2021 Jul 12.

Abstract

The first attempt to control and mitigate an epidemic outbreak caused by a previously unknown virus occurs primarily via non-pharmaceutical interventions (NPIs). In case of the SARS-CoV-2 virus, which since the early days of 2020 caused the COVID-19 pandemic, NPIs aimed at reducing transmission-enabling contacts between individuals. The effectiveness of contact reduction measures directly correlates with the number of individuals adhering to such measures. Here, we illustrate by means of a very simple compartmental model how partial noncompliance with NPIs can prevent these from stopping the spread of an epidemic.

Keywords: COVID-19; Compliance; Epidemic model; Non-pharmaceutical intervention; Reproduction number.