Objective:To investigate the clinical features of neuroendocrine carcinoma of nose and skull base and the efficacy and prognosis of endoscopic resection. Methods:The clinical data of 7 patients with neuroendocrine carcinoma of nose and skull base treated by endoscopic surgery were retrospectively analyzed. According to the international TNM staging, there were 1 case of stage Ⅰ, 1 case of stage Ⅱ, 1 case of stage Ⅲ, 1 case of stage ⅣA and 3 cases of stage ⅣB. All patients were treated by endoscopic surgery, including 1 case of postoperative radiotherapy, 1 case of chemotherapy and 3 cases of radiotherapy and chemotherapy. Results:During the follow-up of 9-58 months, 2 cases died after recurrence, 1 case had ipsilateral cervical lymph node metastasis（tumor-free survival after neck dissection）, and 4 cases had tumor-free survival at the last follow-up. Conclusion:At present, there is no standard treatment for neuroendocrine carcinoma of the nose and skull base. The comprehensive treatment based on complete resection of the tumor by endoscopic surgery is an effective and feasible treatment.
目的：探讨鼻及颅底神经内分泌癌的临床特征及内镜下手术切除的疗效与预后。 方法：回顾性分析7例确诊为鼻及颅底神经内分泌癌并行内镜下手术治疗的患者资料。7例均为小细胞神经内分泌癌，参照国际TNM分期：Ⅰ期1例，Ⅱ期1例，Ⅲ期1例，ⅣA期1例，ⅣB期3例。治疗方法均采用内镜下手术切除，其中术后放疗1例，化疗1例，放化疗3例。 结果：随访9~58个月，2例复发后死亡，1例同侧颈部淋巴结转移（行颈淋巴结清扫术后无瘤生存），4例在最后一次随访中均为无瘤生存。 结论：鼻及颅底神经内分泌癌目前并无标准治疗方案，经内镜手术彻底切除肿瘤为主的综合性治疗是有效可行的治疗方案。.
Keywords: carcinoma, neuroendocrine; endoscopic surgical procedures; nose neoplasms; skull base neoplasms.
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