Objective:To assess the accuracy of the STOP-Bang questionnaire（SBQ） about screening for obstructive sleep apnea（OSA） in adults, and to establish appropriate cutoffs for body mass index（BMI）, neck circumference（NC）, age, and SBQ score for this population in combination with the body size characteristics of the study subjects, and to evaluate the accuracy of the SBQ for combined screening with waist to height ratio（WHtR）. Methods:The data were collected from October, 2019 to November, 2020 at the Affiliated Hospital of Guizhou Medical University, and 218 patients with suspicious OSA were included in this study, all of them completed the SBQ and underwent overnight PSG. SBQ screening and PSG were tested in a blinded concurrent manner. Using the PSG results as the gold standard, the subjects were divided into a diseased group with moderate to severe OSA and a non-diseased group based on apnea hypopnea index. According to SBQ screening results, the subjects were divided into a positive group with moderate severe OSA and negative group. And calculated in the form of four-fold table, the optimal cutoffs were determined by adjusting age, BMI, NC, and SBQ score cutoffs, and calculating the sensitivity, specificity, positive predictive value（PPV）, negative predictive value（NPV）, Youden index, and area under the receiver operating characteristic curve（ROC）. And the modified version of SBQ was combined with WHtR for joint diagnosis to evaluate the accuracy of combined screening. Results:With all 218 patients completing the experiment, 159（72.94%） patients were in the moderate-severe group. The original SBQ had a sensitivity of 93.71%, specificity of 47.46%, PPV of 82.80%, NPV of 73.70%, Youden index of 0.41, and area under the ROC curve（AUC） of 0.71 for predicting moderate to severe OSA. When adjusting the BMI cutoff to 30 kg/m², NC cutoff to 40 cm, and age cutoff to 50 years, the modified SBQ had a sensitivity of 95.60%, specificity of 47.46%, PPV of 83.10%, NPV of 80.00%, Youden index of 0.43, and AUC of 0.72 for predicting moderate to severe OSA. When the modified SBQ score was 4 or more as the cutoff value, the highest Youden index and AUC were 0.54, 0.77 respectively. When the modified SBQ≥3 points were combined with WHtR>0.55, the highest Youden index and AUC were 0.58, 0.79 respectively. Conclusion:SBQ is effective in screening for moderate to severe OSA and better screening accuracy can be achieved by using a modified version of the SBQ（BMI>30 kg/m², NC>40 cm, age>50 years）. The maximum diagnostic accuracy can be achieved when the modified SBQ total score was 4 or more as the cutoff. Those with the modified SBQ total score=3 and WHtR>0.55 can be classified as high risk for moderate to severe OSA, and the modified version of SBQ can be a screening tool to identify moderate to severe OSA.
目的：评估STOP-Bang问卷（SBQ）筛查成人阻塞性睡眠呼吸暂停（OSA）的准确性，并结合研究对象的体型特征，建立适合该人群的体重指数（BMI）、颈围（NC）、年龄、SBQ总分截断值，并评估SBQ与腰高比（WHtR）联合筛查的准确性。 方法：选取2019年10月—2020年11月在贵州医科大学附属医院以打鼾为主要症状就诊的218例可疑OSA患者为研究对象。均完整填写SBQ及进行整夜PSG监测，SBQ筛查与PSG诊断采用盲法同步测试。以PSG结果作为金标准，根据呼吸暂停低通气指数将研究对象分为中重度OSA患病组和非患病组，以SBQ筛查结果将研究对象分为中重度OSA阳性组和中重度OSA阴性组。将问卷结果与金标准以四格表的形式列出，通过调整年龄、BMI、NC、SBQ总分截断值，计算问卷的敏感度、特异度、阳性预测值（PPV）、阴性预测值（NPV）、约登指数，并绘制ROC曲线，计算曲线下面积（AUC），确定最佳的截断值。并将改良版SBQ与WHtR进行联合诊断，评价联合筛查的准确性。 结果：218例全部完成实验，中重度OSA患病组共159例（72.94%），原SBQ对中重度OSA的预测敏感度为93.71%，特异度为47.46%，PPV为82.80%，NPV为73.70%，约登指数为0.41，AUC为0.71。将BMI截断值调整到30 kg/m²、NC截断值40 cm、年龄截断值50岁时的改良版SBQ预测中重度OSA的敏感度为95.60%，特异度为47.46%，PPV为83.10%，NPV为80.00%，约登指数为0.43，AUC为0.72。改良版SBQ总分以≥4分作为截断值时约登指数、AUC最高，分别为0.54、0.77；改良版SBQ≥3分与WHtR>0.55联合筛查时约登指数、AUC最高，分别为0.58、0.79。 结论：SBQ可有效识别中重度OSA，使用改良版SBQ（BMI>30 kg/m²、NC>40 cm、年龄>50岁）可以获得更好的筛查准确性，改良版SBQ总分以≥4分作为截断值筛查准确性更高，SBQ总分=3分且WHtR>0.55者可归入中重度OSA高风险，改良版SBQ可作为识别中重度OSA的筛查工具。.
Keywords: STOP-Bang questionnaires; sleep apnea, obstructive.
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