Wound repair is one of the common clinical problems faced by burn, plastic, and reconstructive surgeons. Current wound repair strategies applied in clinical settings can only achieve pathological repair instead of physiological regeneration. To 'perfectly' repair the defective tissue is the long-time goal of researchers working in this field for a long time. This review introduces the research updates of skin tissue regeneration in wound repair, focusing on the new concept of tissue regeneration technique with stem cells as the core and the construction of scaffold materials for tissue-engineered skin. In summary, making cells proliferate and differentiate into functional skin organ according to the needs of wound healing, regulating the precise location of different cells in the process of wound healing, and reconstructing the normal structure of skin remain the problems needing future explorations.
创面修复是烧伤、整形、修复重建外科医师常面临的临床问题之一。目前临床应用的创面修复策略均只能实现病理性修复而非生理性再生。“完美”地修复缺损组织是相关领域的研究人员长期以来的奋斗目标。本文重点针对以干细胞为核心的组织再生技术和组织工程皮肤支架材料构建的新理念，就创面修复过程中皮肤组织再生的研究进展进行介绍。总的来说，如何根据创面愈合的需要，使细胞增殖分化为功能性皮肤器官，并且在创面愈合过程中对不同细胞的精确定位进行调控，重建皮肤的正常结构，仍是需要不断探索的问题。.