Multiscale models quantifying yeast physiology: towards a whole-cell model

Hongzhong Lu; Eduard J Kerkhoven; Jens Nielsen

doi:10.1016/j.tibtech.2021.06.010

Multiscale models quantifying yeast physiology: towards a whole-cell model

Trends Biotechnol. 2022 Mar;40(3):291-305. doi: 10.1016/j.tibtech.2021.06.010. Epub 2021 Jul 22.

Authors

Hongzhong Lu¹, Eduard J Kerkhoven¹, Jens Nielsen²

Affiliations

¹ Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden.
² Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden; BioInnovation Institute, Ole Maaløes Vej 3, DK2200 Copenhagen N, Denmark. Electronic address: nielsenj@chalmers.se.

PMID: 34303549
DOI: 10.1016/j.tibtech.2021.06.010

Abstract

The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to human health and disease. Yeast was also the first eukaryal organism for which a genome-scale metabolic model (GEM) was developed. In recent years there has been interest in expanding the modeling framework for yeast by incorporating enzymatic parameters and other heterogeneous cellular networks to obtain a more comprehensive description of cellular physiology. We review the latest developments in multiscale models of yeast, and illustrate how a new generation of multiscale models could significantly enhance the predictive performance and expand the applications of classical GEMs in cell factory design and basic studies of yeast physiology.

Keywords: S. cerevisiae; multiscale model; whole-cell model; yeast species.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Models, Biological*
Saccharomyces cerevisiae* / genetics
Saccharomyces cerevisiae* / metabolism