The Cardiovascular Effects of Hydrogen Sulfide: The Epigenetic Mechanisms

Qian Ding; Yi-Zhun Zhu

doi:10.1007/978-981-16-0991-6_8

The Cardiovascular Effects of Hydrogen Sulfide: The Epigenetic Mechanisms

Adv Exp Med Biol. 2021:1315:181-203. doi: 10.1007/978-981-16-0991-6_8.

Authors

Qian Ding^{1

2}, Yi-Zhun Zhu^{3

4}

Affiliations

¹ State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, China.
² Guizhou University of Traditional Chinese Medicine, Guiyang, China.
³ State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, China. yzzhu@must.edu.mo.
⁴ Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. yzzhu@must.edu.mo.

PMID: 34302693
DOI: 10.1007/978-981-16-0991-6_8

Abstract

Hydrogen sulfide (H₂S), known as a gas signal molecule, plays an important role in the development of cardiovascular diseases (CVD) through mechanisms such as angiogenesis, vasodilation, and anti-vascular endothelial cell senescence. Current studies have shown that H₂S can regulate cardiac function through epigenetic regulation. The regulation has opened up a new avenue for the study of CVD development mechanism and H₂S related drug discoveries.

Keywords: Cardiovascular effects; Epigenetics; Hydrogen sulfide.

MeSH terms

Cardiovascular Diseases* / genetics
Cardiovascular System* / metabolism
Epigenesis, Genetic
Humans
Hydrogen Sulfide* / metabolism
Vasodilation

Substances

Hydrogen Sulfide