DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

Mirosław Śnit; Maciej Misiołek; Wojciech Ścierski; Anna Koniewska; Grażyna Stryjewska-Makuch; Sławomir Okła; Władysław Grzeszczak

doi:10.3390/ijerph18147486

DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

Int J Environ Res Public Health. 2021 Jul 13;18(14):7486. doi: 10.3390/ijerph18147486.

Authors

Mirosław Śnit¹, Maciej Misiołek², Wojciech Ścierski², Anna Koniewska², Grażyna Stryjewska-Makuch³, Sławomir Okła⁴, Władysław Grzeszczak⁵

Affiliations

¹ Department and Clinic of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 41-800 Zabrze, Poland.
² Department of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland.
³ Department of Laryngology and Laryngological Oncology, Upper Silesian Medical Centre of Silesian Medical University, 40-055 Katowice, Poland.
⁴ Department of Otolaryngology, Head and Neck Surgery, Holy-Cross Cancer Center, 25-734 Kielce, Poland.
⁵ Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, ul. 3. Maja 13-15, 41-800 Zabrze, Poland.

Abstract

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk.

Patients and methods: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer.

Results: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups.

Conclusions: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

Keywords: DIAPH2; PTPRD and HIC1 gene polymorphisms; laryngeal cancer risk.

MeSH terms

Alleles
Formins
Humans
Kruppel-Like Transcription Factors
Laryngeal Neoplasms* / epidemiology
Laryngeal Neoplasms* / genetics
Polymorphism, Single Nucleotide
Receptor-Like Protein Tyrosine Phosphatases, Class 2

Substances

DIAPH2 protein, human
Formins
HIC1 protein, human
Kruppel-Like Transcription Factors
PTPRD protein, human
Receptor-Like Protein Tyrosine Phosphatases, Class 2