An epidemiological assessment of blood pressure determinants in a random sample of 254 Nigerian adolescents aged 6-17 years in Benin City, Nigeria, was conducted. None of the adolescents reported cigarette smoking. Only 2.6% of the males and 0% of the females were alcohol users. Socio-economic status of the children according to parental education revealed that approximately 23% of the mothers and 9.8% of the fathers received less than a secondary (high school) education. At the other end of the education spectrum, a college education was received by 64.1% and 30.8% of the fathers and mothers, respectively. Two percent of the females and 1.3% of the males either had systolic blood pressures of greater than or equal to 140 mmHg or diastolic blood pressures of greater than or equal to 90 mmHg. No significant blood pressure differences existed between the two sexes. Among the males, it was demonstrated that age, body mass index, and heart rate were significant independent predictors of systolic blood pressure, explaining 49% of the variance. Forty-seven per cent of systolic blood pressure variance was explained by age and heart rate, for females. It was interesting to note that age was the only independent predictor of diastolic blood pressure for both males and females after control for heart rate and body mass index.