Organs-on-chip: The way forward

Massimo Mastrangeli; Janny van den Eijnden-van Raaij

doi:10.1016/j.stemcr.2021.06.015

Organs-on-chip: The way forward

Stem Cell Reports. 2021 Sep 14;16(9):2037-2043. doi: 10.1016/j.stemcr.2021.06.015. Epub 2021 Jul 22.

Authors

Massimo Mastrangeli¹, Janny van den Eijnden-van Raaij²

Affiliations

¹ Delft University of Technology, Delft, the Netherlands. Electronic address: m.mastrangeli@tudelft.nl.
² Human Organ and Disease Model Technologies (hDMT), the Netherlands.

Abstract

Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine. The OoC roadmap can lead the way forward.

Keywords: disease modeling; drug development; microphysiological systems; organ-on-chip; personalized medicine; qualification; roadmap; standardization; stem cell.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Culture Techniques*
Drug Development / instrumentation
Drug Development / methods
Drug Discovery / instrumentation
Drug Discovery / methods
Humans
Lab-On-A-Chip Devices*
Precision Medicine
Stem Cells / cytology*
Stem Cells / metabolism