The Increase of Antileukemic Efficiency of Doxorubicin and Other Cytostatics Combined with Platinum(IV)-Nitroxyl Complex ВС118

S A Goncharova; T A Raevskaya; E N Klimanova; V D Sen'

doi:10.1007/s10517-021-05224-1

The Increase of Antileukemic Efficiency of Doxorubicin and Other Cytostatics Combined with Platinum(IV)-Nitroxyl Complex ВС118

Bull Exp Biol Med. 2021 Jul;171(3):342-346. doi: 10.1007/s10517-021-05224-1. Epub 2021 Jul 23.

Authors

S A Goncharova¹, T A Raevskaya², E N Klimanova², V D Sen'²

Affiliations

¹ Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia. sago@icp.ac.ru.
² Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.

PMID: 34297288
DOI: 10.1007/s10517-021-05224-1

Abstract

Combined treatment of murine leukemia P388 with doxorubicin and platinum(IV)-nitroxyl complex ВС118 administered in low doses improved efficiency of treatment (cure of 83% of animals) without increasing toxicity.

Keywords: antitumor cytostatics; combined therapy; monotherapy; platinum(IV)-nitroxyl complex ВС118; toxicity.

MeSH terms

Animals
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Cytostatic Agents / pharmacology*
Doxorubicin / pharmacology*
Drug Administration Schedule
Leukemia P388 / drug therapy*
Leukemia P388 / mortality
Leukemia P388 / pathology
Longevity / drug effects
Mice
Mice, Inbred DBA
Organoplatinum Compounds / pharmacology*
Survival Analysis

Substances

Cytostatic Agents
Organoplatinum Compounds
VS118
Doxorubicin