Case Report: Analysis of Inflammatory Cytokines IL-6, CCL2/MCP1, CCL5/RANTES, CXCL9/MIG, and CXCL10/IP10 in a Cystic Fibrosis Patient Cohort During the First Wave of the COVID-19 Pandemic

Giulia Baresi; Mauro Giacomelli; Daniele Moratto; Marco Chiarini; Immacolata Claudia Conforti; Rita Padoan; Piercarlo Poli; Silviana Timpano; Francesca Caldarale; Raffaele Badolato

doi:10.3389/fped.2021.645063

Case Report: Analysis of Inflammatory Cytokines IL-6, CCL2/MCP1, CCL5/RANTES, CXCL9/MIG, and CXCL10/IP10 in a Cystic Fibrosis Patient Cohort During the First Wave of the COVID-19 Pandemic

Front Pediatr. 2021 Jul 6:9:645063. doi: 10.3389/fped.2021.645063. eCollection 2021.

Authors

Affiliations

¹ Pediatrics Clinic, "Angelo Nocivelli" Institute of Molecular Medicine, Azienda Socio Sanitaria Territoriale Spedali Civili of Brescia, Brescia University, Brescia, Italy.
² Flow Cytometry, Clinical Chemistry Laboratory, Azienda Socio Sanitaria Territoriale Spedali Civili of Brescia, Brescia, Italy.
³ Cystic Fibrosis Regional Support Center, Azienda Socio Sanitaria Territoriale Spedali Civili of Brescia, Brescia, Italy.

Abstract

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, data registered in the European countries revealed increasing cases of infection in cystic fibrosis (CF) patients. In the course of this pandemic, we enrolled 17 CF patients for a study evaluating inflammatory markers. One of them developed COVID-19, giving us the possibility to analyze inflammatory markers in the acute phase as compared to levels detected before and after the infectious episode and to levels measured in the other CF patients enrolled to the study who did not experience COVID-19 and 23 patients referred to our center for SARS-CoV-2 infection.

Keywords: SARS-CoV-2 infection; T cell activation; cystic fibrosis; cytokines; inflammatory activation.

Publication types

Case Reports