An unusual presentation of Huntington's disease

Martin Schulze Westhoff; Alma Osmanovic; Catharina Meissner; Johannes Heck; Nima Mahmoudi; Corinna Hendrich; Georg Berding; Johanna Seifert; Stefan Bleich; Helge Frieling; Tillmann Krüger; Adrian Groh

doi:10.1002/ccr3.4547

An unusual presentation of Huntington's disease

Clin Case Rep. 2021 Jul 16;9(7):e04547. doi: 10.1002/ccr3.4547. eCollection 2021 Jul.

Affiliations

¹ Department of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.
² Department of Neurology Hannover Medical School Hannover Germany.
³ Institute for Clinical Pharmacology Hannover Medical School Hannover Germany.
⁴ Department of Diagnostic and Interventional Neuroradiology Hannover Medical School Hannover Germany.
⁵ Institute for Human Genetics Hannover Medical School Hannover Germany.
⁶ Department of Nuclear Medicine Hannover Medical School Hannover Germany.

Abstract

We describe the case of a 59-year-old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F-FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive supranuclear palsy, genetic testing eventually revealed Huntington's disease.

Keywords: 18F‐FDG PET/CT; Huntington's disease; frontotemporal dementia; psychosis; tauopathies.

Publication types

Case Reports