Association between coronary artery calcium score on non-contrast chest computed tomography and all-cause mortality among patients with congestive heart failure

Kyoko Ota; Rine Nakanishi; Hidenobu Hashimoto; Yuriko Okamura; Ippei Watanabe; Takayuki Yabe; Ryo Okubo; Takanori Ikeda

doi:10.1007/s00380-021-01906-y

Association between coronary artery calcium score on non-contrast chest computed tomography and all-cause mortality among patients with congestive heart failure

Heart Vessels. 2022 Feb;37(2):262-272. doi: 10.1007/s00380-021-01906-y. Epub 2021 Jul 22.

Authors

Kyoko Ota¹, Rine Nakanishi², Hidenobu Hashimoto³, Yuriko Okamura¹, Ippei Watanabe³, Takayuki Yabe³, Ryo Okubo³, Takanori Ikeda¹

Affiliations

¹ Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
² Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan. rine.n@med.toho-u.ac.jp.
³ Division of Cardiovascular Medicine, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.

PMID: 34292390
DOI: 10.1007/s00380-021-01906-y

Abstract

Coronary artery calcium (CAC) score is a robust prognostic tool to predict cardiac events. Although patients with congestive heart failure (CHF) occasionally undergo non-contrast computed tomography (NCCT), the prognostic utility of CAC by NCCT is not widely known. We aimed to determine if CAC measured on NCCT is associated with all-cause mortality (ACM) among patients with CHF. We identified 550 patients admitted due to CHF who underwent NCCT. Patients were categorized into three groups according to CAC scores 0, 1-999, and ≥ 1000. The multivariate Cox proportional hazards model was used to assess if CAC by NCCT was associated with ACM after adjusting for traditional coronary artery disease (CAD) risk factors, brain natriuretic peptide and left ventricular ejection fraction (LVEF). In a subset of 245 patients with invasive coronary angiography (ICA), the associations between CAC scores and ACM were assessed in the multivariate Cox proportional hazards model. Further, we assessed if CAC increased statin use at discharge. During a mean follow-up of 3.3 ± 3.1 years, ACM occurred in 168 patients (30.55%). Compared with patients with CAC 0, those with CAC ≥ 1000 (HR 1.564, 95% CI 0.969-2.524, P = 0.067) were more likely to experience ACM, while those with CAC score 1-999 (HR 0.971, 95% CI 0.673-1.399, P = 0.873) were not. Similarly, a trend toward significance was observed in patients with LVEF < 40% (HR 2.124, 95% CI 0.929-4.856, P = 0.074). In the sub-analysis, patients with CAC ≥ 1000 had increased ACM compared to those with CAC 0, only if ICA ≥ 50% (HR 3.668, 95% CI 1.141-11.797, P = 0.029). Multivariate logistic regression revealed that statin use at discharge was increased with ICA ≥ 50%, but not CAC. The CAC score measured by NCCT tended to be associated with ACM among CHF patients. Statin use was not increased by CAC on NCCT.

Keywords: Congestive heart failure; Coronary artery calcium score; Coronary artery disease; Non-contrast chest computed tomography; Statin use.

MeSH terms

Calcium
Coronary Angiography / methods
Coronary Artery Disease* / diagnosis
Coronary Artery Disease* / diagnostic imaging
Heart Failure* / diagnostic imaging
Heart Failure* / etiology
Humans
Prognosis
Risk Assessment
Risk Factors
Stroke Volume
Tomography, X-Ray Computed
Vascular Calcification* / complications
Vascular Calcification* / diagnostic imaging
Ventricular Function, Left

Substances

Calcium