Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States

Guoying Zhu; Qing Fang; Fengshang Zhu; Dongping Huang; Changqing Yang

doi:10.3389/fgene.2021.693538

Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States

Front Genet. 2021 Jul 5:12:693538. doi: 10.3389/fgene.2021.693538. eCollection 2021.

Authors

Guoying Zhu^{1

2}, Qing Fang¹, Fengshang Zhu³, Dongping Huang¹, Changqing Yang³

Affiliations

¹ Department of Clinical Nutrition, Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, China.
² Department of Pediatrics Gastroenterology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
³ Department of Gastroenterology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PTL or PNLIP) and its family members, pancreatic lipase-related protein 1 (PNLIPRP1or PLRP1) and pancreatic lipase-related protein 2 (PNLIPRP2 or PLRP2). Unlike the family's other members, PNLIPRP2 plays an elemental role in lipid digestion, especially for newborns. Therefore, if genetic factors cause gene mutation, or other factors lead to non-expression, it may have an effect on fat digestion and absorption, on the susceptibility to pancreas and intestinal pathogens. In this review, we will summarize what is known about the structure and function of PNLIPRP2 and the levels of PNLIPRP2 and associated various pathological states.

Keywords: fat digestion; intestinal absorption; pancreatic lipase; pancreatic lipase related protein 2; polymorphism.

Publication types

Review