Abstract
Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.
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MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Child
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Child, Preschool
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Febrile Neutropenia / drug therapy*
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Febrile Neutropenia / microbiology*
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Female
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Humans
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Leukemia / complications*
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Leukemia / microbiology
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Male
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Microbial Sensitivity Tests
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Practice Guidelines as Topic
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Prospective Studies
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Streptococcal Infections / drug therapy*
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Vancomycin / therapeutic use*
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Viridans Streptococci / drug effects*
Substances
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Anti-Bacterial Agents
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Vancomycin