Abstract
Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (1-8), together with four known α-pyrones, were isolated from the leaves and twigs of Cryptocarya yunnanensis. The structures of 1-8 including their absolute configurations were characterized by spectroscopic data analysis and single-crystal X-ray crystallography. Plausible biosynthetic pathways for the formation of compounds 1-8 were proposed. Compounds 1-4 exhibited cytotoxicity against HCT-116, MDA-MB-231, and PC-3 cancer cells with IC50 values from 6.4 to 9.1 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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China
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Cryptocarya / chemistry*
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Drug Screening Assays, Antitumor
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Flavanones / isolation & purification
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Flavanones / pharmacology*
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Humans
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Molecular Structure
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Phytochemicals / isolation & purification
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Phytochemicals / pharmacology
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Plant Leaves / chemistry
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Pyrones / isolation & purification
Substances
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Antineoplastic Agents, Phytogenic
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Flavanones
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Phytochemicals
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Pyrones