The Clinical Significance and Utility of HPV-DNA Testing in Korean Women with Atypical Glandular Cells in Cervical Pap Tests: An Analysis of 311 Cases at a Single Institution

Cancer Invest. 2021 Nov;39(10):885-892. doi: 10.1080/07357907.2021.1952593. Epub 2021 Sep 3.

Abstract

The aim of this study is to analyze the correlation between clinically significant histologic results and HPV in women with AGC in pap test. Of the 311 women confirmed as AGC, 111 women (35.7%) was identified as positive for HPV. In the AGC analysis, cervical lesions were significantly more common in HPV positive group compared to HPV negative group (61.2 vs. 10.5%, p < 0.001). In contrast, endometrial lesions were not associated with HPV infection (8.1 vs. 4.5%, p = 0.12). The HPV-DNA testing in women with AGC may be a useful tool for predicting clinically significant cervical lesions.

Keywords: Atypical glandular cells; Pap test; human papillomavirus.

MeSH terms

  • Adult
  • Aged
  • Cervix Uteri / pathology*
  • DNA, Viral / analysis*
  • Female
  • Humans
  • Middle Aged
  • Papanicolaou Test*
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Precancerous Conditions / virology*
  • Uterine Cervical Neoplasms / virology*
  • Young Adult

Substances

  • DNA, Viral