Factors associated with corneal high-order aberrations before and after femtosecond laser-assisted in situ keratomileusis

Jun Zeng; Gongpu Lan; Min Zhu; Kai Sun; Qun Shi; Guoqing Ma; Quan Liu

doi:10.21037/atm-21-2367

Factors associated with corneal high-order aberrations before and after femtosecond laser-assisted in situ keratomileusis

Ann Transl Med. 2021 Jun;9(12):989. doi: 10.21037/atm-21-2367.

Authors

Jun Zeng^{1

2}, Gongpu Lan³, Min Zhu¹, Kai Sun¹, Qun Shi⁴, Guoqing Ma⁴, Quan Liu²

Affiliations

¹ Department of Ophthalmology, The First People's Hospital of Foshan, Foshan, China.
² State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China.
³ School of Physics and Optoelectronic Engineering, Foshan University, Foshan, China.
⁴ School of Automation, Foshan University, Foshan, China.

Abstract

Background: Corneal high-order aberrations (HOAs) are related to visual quality. However, the factors associated with corneal HOAs before and after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) have not yet been elucidated. The aim of this study is to observe the factors related to corneal HOAs before and after FS-LASIK.

Methods: Prospective observational study was designed to measure corneal HOAs in 149 eyes of 75 patients before and 6 months after FS-LASIK. The relationship between spherical diopter and corneal parameters, including K1 and K2 (horizontal and vertical refractive power of the cornea, respectively), the aspheric characteristics of the cornea (Q), mean radius of the curvature of the cornea (Rm), and central corneal thickness (CCT), with corneal HOAs were analyzed.

Results: The spherical diopter was correlated with trefoil at 30° before surgery and with vertical coma, four-order astigmatism at 0°, trefoil at 30°, spherical aberration, and six-order spherical aberration after surgery (P<0.05). CCT was correlated with vertical coma, four-order astigmatism at 0°, trefoil at 30°, and six-order spherical aberration after surgery (P<0.05). K1 was correlated with spherical aberration and six-order astigmatism at 0° before surgery (P<0.05). K2 was correlated with spherical aberration, six-order astigmatism at 45°, astigmatism at 0°, six-order astigmatism at 0° before surgery, and trefoil at 30° after surgery (P<0.05). Q was correlated with spherical aberration, six-order spherical aberration, and six-order astigmatism at 45° (P<0.05). Rm was correlated with six-order astigmatism at 0°, spherical aberration, six-order astigmatism at 45° before surgery, and astigmatism at 0° after surgery (P<0.05).

Conclusions: Corneal parameters and spherical diopter are related to the HOAs of the cornea before and after FS-LASIK.

Keywords: Corneal high-order aberrations (HOAs); corneal parameters; femtosecond laser-assisted in situ keratomileusis (FS-LASIK); spherical diopter; visual quality.