Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

Udisha Singh; Vinod Morya; Bhaskar Datta; Chinmay Ghoroi; Dhiraj Bhatia

doi:10.3389/fchem.2021.704234

Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

Front Chem. 2021 Jun 30:9:704234. doi: 10.3389/fchem.2021.704234. eCollection 2021.

Authors

Udisha Singh¹, Vinod Morya¹, Bhaskar Datta^{1

2}, Chinmay Ghoroi^{2

3}, Dhiraj Bhatia^{1

2}

Affiliations

¹ Biological Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, India.
² Center for Biomedical Engineering, Indian Institute of Technology Gandhinagar, Palaj, India.
³ Chemical Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, India.

Abstract

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.

Keywords: DNA nanotechnology; biomedical applications; biosensing; stimulus responsive devices; therapeutics.

Publication types

Review